Compare Hypotheses
Wound-Induced Topological Defects Serve as Transient Stem Cell Attractors That Become Permanent Niches When Pinned by ECM Stiffness Gradients
Wounds may accidentally create geometric 'whirlpools' in tissue that trap stem cells and become permanent repair centers.
Organoid Symmetry Breaking Is a Topological Defect Nucleation Event -- Predictable by Active Nematic Theory and Controllable by Geometric Confinement
The spots where mini-organs sprout new buds may be predictable using the same math that governs liquid crystals.
Activity-Dependent Crypt Fission Is Triggered When Local Epithelial Contractility Exceeds the Nematic Defect-Splitting Threshold
Gut stem cell 'budding' may be triggered by the same physics that makes liquid crystals split.
All Hypotheses
Wound-Induced Topological Defects Serve as Transient Stem Cell Attractors That Become Permanent Niches When Pinned by ECM Stiffness Gradients
PASSWounds may accidentally create geometric 'whirlpools' in tissue that trap stem cells and become permanent repair centers.
Organoid Symmetry Breaking Is a Topological Defect Nucleation Event -- Predictable by Active Nematic Theory and Controllable by Geometric Confinement
PASSThe spots where mini-organs sprout new buds may be predictable using the same math that governs liquid crystals.
Activity-Dependent Crypt Fission Is Triggered When Local Epithelial Contractility Exceeds the Nematic Defect-Splitting Threshold
PASSGut stem cell 'budding' may be triggered by the same physics that makes liquid crystals split.