Cuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
5 HYPOTHESESCell BiologyGeochemistry
Compare Hypotheses
HYPOTHESIS
SCORECGVERDICT
Fe-S Cluster Cu Displacement (Geochemical Cu-Fe Replacement Series)
5.055PASS
FDX1 Redox Potential Tuned to Vent Cu²⁺/Cu⁺ Boundary
5.055CONDITIONAL
H₂S–CuS Nanoparticle Feed-Forward Loop
5.055CONDITIONAL
Dithiolane–Chalcopyrite Ligand Homology
5.055CONDITIONAL
Evolutionary FDX1-LIAS Reconstruction
5.055CONDITIONAL
All Hypotheses
Fe-S Cluster Cu Displacement (Geochemical Cu-Fe Replacement Series)
PASSCuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
Cell BiologyGeochemistry
5Score
5Confidence
5Grounded
FDX1 Redox Potential Tuned to Vent Cu²⁺/Cu⁺ Boundary
CONDITIONALCuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
Cell BiologyGeochemistry
5Score
5Confidence
5Grounded
H₂S–CuS Nanoparticle Feed-Forward Loop
CONDITIONALCuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
Cell BiologyGeochemistry
5Score
5Confidence
5Grounded
Dithiolane–Chalcopyrite Ligand Homology
CONDITIONALCuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
Cell BiologyGeochemistry
5Score
5Confidence
5Grounded
Evolutionary FDX1-LIAS Reconstruction
CONDITIONALCuproptosis (copper-dependent cell death via lipoylated protein aggregation)
Hydrothermal vent Cu-S geochemistry (chalcopyrite, Pourbaix diagrams, Irving-Williams series)
Cell BiologyGeochemistry
5Score
5Confidence
5Grounded