Ferroptosis (iron-dependent cell death via lipid peroxidation)
Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
4 HYPOTHESESCell & Molecular BiologyEarth & Planetary Science

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Abiotic vs Enzymatic PLOOH Regioselectivity as Chemical Fossil of Antioxidant Evolution

PASS
Ferroptosis (iron-dependent cell death via lipid peroxidation)
Radical selectivity contrast
Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
Cell & Molecular BiologyEarth & Planetary Science

The chemical chaos of ancient iron reactions may have driven evolution of the precise cellular death machinery we carry today.

10Score
5Confidence
7Grounded

Ferritin Protein Shell as Kinetic Barrier Controlling Ferrihydrite Fenton Activity

PASS
Ferroptosis (iron-dependent cell death via lipid peroxidation)
Ferrihydrite nanoparticle Fenton catalysis kinetics
Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
Cell & Molecular BiologyEarth & Planetary Science

The protein cage around our cellular iron stores may act as a firewall against runaway chemical reactions that destroy cells.

10Score
5Confidence
6Grounded

Pourbaix Stability Field Mapping of Ferrihydrite-Catalyzed PLOOH Production

PASS
Ferroptosis (iron-dependent cell death via lipid peroxidation)
Pourbaix iron stability fields
Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
Cell & Molecular BiologyEarth & Planetary Science

A geochemist's pH-voltage map could explain exactly where and when iron triggers the cell death behind cancer and neurodegeneration.

9Score
5Confidence
6Grounded

PHREEQC Iron Speciation Model Predicts GSH-Dependent Fenton Activity Amplification

PASS
Ferroptosis (iron-dependent cell death via lipid peroxidation)
Aqueous speciation thermodynamics
Serpentinization geochemistry (abiotic Fe(II)/Fe(III) redox cycling)
Cell & Molecular BiologyEarth & Planetary Science

A geology chemistry tool may reveal how iron becomes deadly in cells — but only at the last moment before cell death.

9Score
4Confidence
6Grounded