Health, Medicine & Pharmacology
The science of disease, therapeutic intervention, and drug development — from drug delivery and toxicology to cancer biology and clinical pharmacology.
All Hypotheses
Adenosine-CXCL9 Turing Instability Generates Periodic Immune Hot/Cold Zones in Solid Tumors
Tumors may create immune hot and cold zones through the same math that gives zebras their stripes.
ERK-Dependent Caldesmon Phosphorylation Creates Rheological Checkpoint: MEK Inhibitor Repurposing for LMS Anti-Invasion
Cancer cells may only invade when a molecular switch makes them physically soft enough — and a known drug could reset that switch.
Dual Saturation Index Competition Predicts LLPS vs. Crystallization Pathway Switching in Ionizable Drug ASD Dissolution
Equations from volcano science could predict whether experimental drugs dissolve properly or crash out as useless crystals.
TST Dissolution Kinetics in the Surface-Reaction-Limited Regime of Low Drug-Loading ASDs
A volcano-rock chemistry equation could predict how poorly soluble drugs dissolve from pharmaceutical formulations.
Grambow Rate Law 2 Predicts Competitive Passivation-Erosion Kinetics and Regime Switching in ASD Dissolution
A geology equation used to model volcanic rock dissolving could predict how poorly-soluble drugs release in the body.
Desmin Cage Compressive Stiffness Determines Nuclear Rupture Threshold: Quantitative Chromothripsis Accumulation Rate
Losing a protein 'cage' around cancer cell nuclei may cause DNA to shatter, making tumors more aggressive over time.
MYH11 Paradoxical Self-Limiting Invasion Through Excessive Contractile Stress
In rare muscle cancers, too much cellular force may actually stop tumors from spreading — more power, less invasion.
Two-Component Rheological Barrier: Caldesmon + Calponin Synergistic Anti-Invasion Effect
Two muscle proteins may act as a tag-team force field that blocks cancer cells from spreading through tissue.
Mn-OP Mimetics as Dual-Function Neuroprotectants: MnSOD Supplementation + Mismetalation Prevention
Copying a radiation-proof bacterium's manganese tricks could protect human brain cells from toxic metal damage.
Nucleation-Controlled Ostwald Ripening with Polymer Inhibition Predicts ASD Phase Evolution Trajectories
Volcanic rock chemistry could unlock a precise formula for how poorly soluble drugs dissolve in the body.
EPR-Detectable Free Mn2+ Fraction as Diagnostic Biomarker for Mn Neurotoxicity Risk
A bacterial survival trick could reveal which form of manganese in your blood predicts brain damage risk.
Compartment-Specific Mn-OP Formation in Mitochondria Explains Protective vs Toxic Mn Pools
Where manganese hides inside cells may determine whether it heals or harms.
In Vitro Turing Pattern Formation in 3D Tumor-Immune Spheroid Co-Cultures
Immune cells inside tumors may self-organize into patterns governed by the same math as animal stripes.
PGE2-CXCL9 Turing System Explains the Spatial Selectivity of Aspirin's Anti-Tumor Effect in CRC
Aspirin may fight colon cancer by scrambling the molecular 'pattern' that keeps immune cells locked out of tumors.
Mn Speciation as the Missing Variable in Manganese Neurotoxicity: A Unifying Framework
The form manganese takes chemically may determine whether it heals or harms the brain.
Stress Fiber Yielding Dynamics Set Pulsatile LMS Invasion Frequency: Laser Ablation Dissection
Cancer cells may invade surrounding tissue in rhythmic pulses timed by the slow snap-and-recover cycle of their internal scaffolding.
IFN-gamma Simultaneously Drives Activator and Inhibitor in IDO1-Expressing Tumors — A Self-Organizing Turing Bifurcation
Tumors may use a single immune signal to simultaneously attract and repel killer cells in a self-organizing pattern.
Irving-Williams-Guided Mn Speciation Framework for Metal-Specific Neurotoxicity
The chemical rules governing metal competition could explain why manganese harms the brain in some forms but not others.
Turing Proximity Score (TPS) from Pre-Treatment Spatial Transcriptomics Predicts Checkpoint Inhibitor Response
A math formula from the 1950s might predict which cancer patients respond to immunotherapy.
Pressure-Fracture Competition Regime Map for ASD Manufacturing Optimization
Volcano science could predict how poorly soluble drugs dissolve — and when manufacturing goes wrong.
MMP/LOX Ratio as a Percolation Clock -- Separating Dynamic Percolation Windows from Salmon 2012 Fiber Alignment
A molecular ratio in tumors may act like a clock that controls when immune cells can — or can't — get inside.
Velocity Autocorrelation Signature Distinguishes Percolation Subdiffusion from T Cell Run-and-Pause
A physics fingerprint could reveal why immune cells get stuck at the edge of tumors.
CXCL9/10 Gradient Steepness as Pe-Based Percolation Phase Diagram Classifier
A physics model of network connectivity could predict whether immune cells can infiltrate tumors.
Exponent-Agnostic Universality Class Measurement -- From Assumed nu=0.88 to Measured Critical Exponent via Active-Particle Crossover
Physics models of connectivity could reveal how tumors physically wall off immune cells — if the math holds up.
LOX-Mediated Collagen Crosslink Density as Bond Occupation Probability -- Corrected Pore Geometry and Heterogeneity-Smeared Transition
Stiffening tumor scaffolding may hit a tipping point that physically locks immune cells out of cancers.
BAPN Percolation Titration -- Corrected LOX Inhibitor Citation and Quantified p(dose) Mapping Function
Could a math model from physics predict the right drug dose to stop tumors from hiding from the immune system?