Organismal & Evolutionary Biology
How multicellular organisms develop, function, sense their environments, and evolve — spanning plants, animals, and the ecological relationships between them.
All Hypotheses
Aortoiliac chi Deviation + Stiffness Gradient Mahalanobis Distance: UK Biobank MACE Biomarker with Sign-Change-Aware Construction
How the geometry of your aorta's fork could predict heart attacks better than standard tests.
Biofilm Aggregate Modulus (H_a) from Confined Compression Predicts Mechanical Resistance to Debridement Better Than G'/G''
A cartilage physics trick could finally explain why scrubbing away bacterial slime is harder than it looks.
Central Pressure Waveform Sample Entropy as Empirical Biomarker of Waveform Morphology Simplification, Agnostic to Sugawara-vs-Hashimoto Reflection Debate
Measuring the 'complexity' of heartbeat pressure waves could reveal arterial aging without settling an ongoing scientific debate.
Starchless Mutant Allelic Series as Quantitative Test of CRB N-Scaling
Counting starch granules in plant cells could reveal the mathematical limits of how plants sense gravity.
Cross-Species CRB Landscape Predicts Gravitropic Precision Hierarchy Across Statolith-Based Plant Organs
A math formula from statistics could predict exactly how precisely different plants sense gravity — and why some are better at it than others.
CRB Framework Makes Testable Predictions at 1-10 Degree Range Through N-Dependent Precision Scaling
A statistics theorem from the 1940s may reveal the fundamental precision limits of how plants sense gravity.
Fixed Charge Density (FCD) of P. aeruginosa Alginate Biofilm Predicts Donnan-Mediated Cationic Antibiotic Partitioning
Borrowing physics from cartilage research could explain why certain antibiotics get trapped outside stubborn bacterial slime.
Fetal Aortoiliac Area-Ratio as Constitutional Predictor of Adult cfPWV Trajectory: Differentiated from Barker via Geometry-Specific Mediation and a Shorter-Horizon Proxy Test
The geometry of your aorta set before birth may quietly predict how fast your arteries age over a lifetime.
Bifurcation Trajectory Entropy (BTE) Grounded in Greenwald 1990 Monotonic Gamma Trajectory: Spatial Entropy of the Aortoiliac-to-Femoral Reflection Landscape as Aging Biomarker
Mapping how efficiently your arteries branch could reveal aging and heart risk better than current blood pressure tests.
Information-Geometric Phase Transition Predicts Mutant-Specific Threshold Shifts in Gravitropic Dose-Response
A math theory used in spy satellites could reveal why plants know which way is down — with a precise prediction to test it.
Net Fixed Charge Density Transitions from Positive to Negative During Biofilm Maturation
Dangerous lung bacteria may have a brief 'charge-neutral' window where antibiotics can slip past their defenses.
Information Bottleneck Matching in Gravitropic Cascade Revealed by Single-Factor Perturbation Asymmetry
Plants may have evolved perfectly matched signal-processing steps to sense gravity as efficiently as physics allows.
Streaming Potential Measurement Reveals Spatial FCD Heterogeneity in Mixed-EPS Biofilm
A technique for measuring electrical charges in joint cartilage could map the hidden architecture of antibiotic-resistant bacterial slime.
Statolith Size Polydispersity as Natural Experiment — Larger Statoliths Carry More Fisher Information Per Unit Mass
Bigger plant gravity sensors may pack exponentially more information — and math predicts exactly how much.
Sequential Two-Phase Bivalent Enhancer Activation Under ECM Stiffness
Stiff tissues may flip cancer genes in two distinct steps — and we might be able to block just the dangerous second one.
HDAC3-NCoR Eraser Depletion by ECM Stiffness Creates Enhancer Stabilization Independent of Writer Activation
Stiff tissues may rewire gene activity by silencing a molecular eraser, not by switching writers on.
Mechanically-Induced H3K27ac as 6-12h Temporal Window for TET2-Mediated CpG Demethylation -> DNA Methylation Mechanical Memory
Cells may 'remember' physical hardness through chemical tags on DNA — with a critical 6-12 hour window to lock it in.
Lamin A/C Concentration Sets the Cell-Intrinsic Stiffness-Sensing Threshold for Mechanoenhancer Activation
The amount of a nuclear scaffolding protein may determine how sensitive cells are to their physical surroundings.
Integrin Force-Induced H3K9me3 Demethylation Creates Competence Windows for H3K27ac
Physical forces from a cell's surroundings could unlock DNA regions to switch genes on or off.
Dual YAP-TEAD + MRTF-SRF Programs in CTCF-Permitted Loop Domains
How cells sense physical forces may be written into the very folding structure of our DNA.
Two-Phase Mechanoenhancer Activation Constitutes a Temporal Coincidence Gate
Cells may use a two-step timing trick to 'decide' whether to permanently remodel their DNA activity in response to physical forces.
MRTF-A Preferentially Occupies Mechanoenhancers over Promoters on Stiff ECM, Defining a Non-TEAD Mechanical Enhancer Program
How cells sense tissue stiffness may rewrite gene activity through hidden DNA 'volume knobs' — not just on-off switches.
YAP-BRD4 Condensate Size Supralinearly Encodes ECM Stiffness, Creating a Mechanical Switch at Mechanoenhancers
Cells may sense tissue stiffness with dramatic amplification, flipping a molecular switch that turbocharges gene activity.
KDM6B-Mediated Bivalent Mechanoenhancer Resolution as Epigenetic Ratchet in IPF Fibrosis
Scar tissue may lock its own fate by using physical stiffness to permanently rewrite DNA's instruction manual.
YAP-BRD4 Condensate Volume Threshold Drives Looping-Independent Multi-Enhancer Hub Formation
How a cell's physical environment might rewire its DNA activity through protein droplets crossing a critical size threshold.