Physics & Biophysics
The principles of physics applied across scales — from quantum phenomena in living systems and soft materials to thermodynamics, statistical mechanics, and the physics of active matter.
Topics
All Hypotheses
Aortoiliac chi Deviation + Stiffness Gradient Mahalanobis Distance: UK Biobank MACE Biomarker with Sign-Change-Aware Construction
How the geometry of your aorta's fork could predict heart attacks better than standard tests.
ERK-Dependent Caldesmon Phosphorylation Creates Rheological Checkpoint: MEK Inhibitor Repurposing for LMS Anti-Invasion
Cancer cells may only invade when a molecular switch makes them physically soft enough — and a known drug could reset that switch.
Variance-Component Decomposition of E. coli Adder — DnaA Counting Dominant at Fast Growth
Bacteria switch which internal clock controls their size depending on how fast they're growing.
Central Pressure Waveform Sample Entropy as Empirical Biomarker of Waveform Morphology Simplification, Agnostic to Sugawara-vs-Hashimoto Reflection Debate
Measuring the 'complexity' of heartbeat pressure waves could reveal arterial aging without settling an ongoing scientific debate.
FtsZ GTPase ~2000× Over-Dissipating vs DnaA — Precision Bottleneck at Initiation Not Division
Bacteria waste energy at cell division, but the real precision clock ticks at the moment DNA copying begins.
Maxwell Relaxation Time Aging Exponent beta_M in FUS-P525L Condensates
Tracking how fast diseased protein droplets 'solidify' could reveal a hidden clock in ALS progression.
Desmin Cage Compressive Stiffness Determines Nuclear Rupture Threshold: Quantitative Chromothripsis Accumulation Rate
Losing a protein 'cage' around cancer cell nuclei may cause DNA to shatter, making tumors more aggressive over time.
MYH11 Paradoxical Self-Limiting Invasion Through Excessive Contractile Stress
In rare muscle cancers, too much cellular force may actually stop tumors from spreading — more power, less invasion.
Two-Component Rheological Barrier: Caldesmon + Calponin Synergistic Anti-Invasion Effect
Two muscle proteins may act as a tag-team force field that blocks cancer cells from spreading through tissue.
Bifurcation Trajectory Entropy (BTE) Grounded in Greenwald 1990 Monotonic Gamma Trajectory: Spatial Entropy of the Aortoiliac-to-Femoral Reflection Landscape as Aging Biomarker
Mapping how efficiently your arteries branch could reveal aging and heart risk better than current blood pressure tests.
Fetal Aortoiliac Area-Ratio as Constitutional Predictor of Adult cfPWV Trajectory: Differentiated from Barker via Geometry-Specific Mediation and a Shorter-Horizon Proxy Test
The geometry of your aorta set before birth may quietly predict how fast your arteries age over a lifetime.
Multi-Spectral Vibronic Coherence Transfer Between Photosynthetic Complexes
Photosynthesis may work as a quantum team sport, with energy vibrations leaping between separate cellular machines.
Probe-Size-Scaling Exponent nu_SE in TDP-43 Condensates with K_p(r) Deconvolution and Scaffold-Chemistry Control
Tracking how differently-sized probes move inside disease proteins could reveal when cells lose the ability to dissolve toxic clumps.
DeltaDeltaG Mutant Scanning of FhuA Loops L3/L10 with T5 pb5 Distinguishes Fitness-Constrained vs Free Resistance Mutations, with Phase-Variation Rate Included as a Competing Pathway
Measuring binding energy could predict which bacterial mutations will actually resist a virus — and which ones cost too much to survive.
Mutual Information I(X;Y) as Model-Free Liquidity Metric for Condensate State
Measuring how 'liquid' a cell's droplets are by tracking whether molecules move in sync — no physics model required.
ppGpp → Supercoiling → N_eff Reduction as Stress-Responsive TUR Tuning
Bacteria may tune their energy efficiency during stress by physically twisting their DNA to blur internal counting signals.
Stress Fiber Yielding Dynamics Set Pulsatile LMS Invasion Frequency: Laser Ablation Dissection
Cancer cells may invade surrounding tissue in rhythmic pulses timed by the slow snap-and-recover cycle of their internal scaffolding.
TUR Dominates Berg-Purcell for DnaA-oriC — Thermodynamic Not Diffusive Bottleneck
The energy a bacterium burns, not random molecular collisions, may be the true limit on how precisely it copies its DNA.
Multi-Current TUR Decomposition — Noise Portfolio
Bacteria may balance cell growth noise like a financial portfolio, trading precision for energy efficiency.
Refined Hierarchical Spectral Scoring with Yu et al. D_misfold Calibration and Cross-Validation Against TANGO/CamSol
A physics quirk about how systems cool could reveal why some proteins misfold into brain-destroying clumps.
Cooling-Rate-Dependent Fibril Polymorph Selection in Insulin: Three-Arm Mechanism Discrimination
Could the speed of cooling dictate which dangerous protein shape forms — and could a physics quirk help us control it?
Quantitative Vibronic Coherence Extension in PSII Reaction Centers
Protein vibrations in plant cells may keep quantum effects alive long enough to supercharge photosynthesis.
ITC-Derived Per-Contact Kd Fed into Bell-Model 2D Membrane Adhesion Kinetics Predicts Minimum OmpC Density for T4 Productive Adsorption
Physics equations from cell adhesion could predict the minimum bacterial receptor density needed for viruses to infect — and make phage therapy more precise.
ITC Entropy Dominance (DeltaH/DeltaG < 0.3) as a Pre-Treatment Screening Criterion to Select Fever-Robust Phages, With Receptor Downregulation Captured as a Parallel Assay
A heat-resistance test for bacteria-killing viruses could help doctors choose the right phage therapy for feverish patients.
Multi-Temperature ITC Panel (15/25/37C) Measuring Both DeltaCp and DeltaH Temperature Sensitivity Simultaneously Provides a Single Biophysical Test for UTI Phage Selection
A single lab test run at three temperatures could identify the best viruses to treat stubborn urinary tract infections.
RIDA Kinetic Timing Window — U-Shaped CV vs Hda Titration
Bacteria may tune cell division timing using a physical law that links speed, accuracy, and energy costs.
ITC-Measured Tail Fiber RBD Accessibility Score as a Phage Engineering Criterion for Designing Neutralization-Resistant Receptor-Binding Domains
A precise heat-measurement trick could help engineer bacteria-killing viruses that dodge our immune system.
Spectral Entropy Production Rate Distinguishes Folding from Misfolding Pathways in Non-Equilibrium Protein Dynamics
The rate at which proteins shed disorder could reveal whether they fold correctly or misfold into disease-causing clumps.
Mpemba-Guided Aggregation Inhibitor Design: Small Molecules That Maximize Eigenmode Overlap Disruption
A quirky physics phenomenon about water cooling could inspire smarter drugs to stop Alzheimer's proteins from clumping.
Min Pareto-Frontier TUR with Pattern Instability Bifurcation
Bacteria may use energy inefficiency as a feature, not a bug, to reliably control their own size.
MMP/LOX Ratio as a Percolation Clock -- Separating Dynamic Percolation Windows from Salmon 2012 Fiber Alignment
A molecular ratio in tumors may act like a clock that controls when immune cells can — or can't — get inside.
Chaperone-Modulated Mpemba Index: Hsp70 Binding Selectively Reduces Slow-Eigenmode Overlap, Constituting a Biological Mpemba Protocol
Heat-shock proteins may accidentally trigger a physics shortcut that helps misfolded proteins reach healthy states faster.
Velocity Autocorrelation Signature Distinguishes Percolation Subdiffusion from T Cell Run-and-Pause
A physics fingerprint could reveal why immune cells get stuck at the edge of tumors.
CXCL9/10 Gradient Steepness as Pe-Based Percolation Phase Diagram Classifier
A physics model of network connectivity could predict whether immune cells can infiltrate tumors.
LOX-Mediated Collagen Crosslink Density as Bond Occupation Probability -- Corrected Pore Geometry and Heterogeneity-Smeared Transition
Stiffening tumor scaffolding may hit a tipping point that physically locks immune cells out of cancers.
Exponent-Agnostic Universality Class Measurement -- From Assumed nu=0.88 to Measured Critical Exponent via Active-Particle Crossover
Physics models of connectivity could reveal how tumors physically wall off immune cells — if the math holds up.
BAPN Percolation Titration -- Corrected LOX Inhibitor Citation and Quantified p(dose) Mapping Function
Could a math model from physics predict the right drug dose to stop tumors from hiding from the immune system?
Evolutionary Mpemba Tradeoff: Amyloidogenic Sequences Persist Because High Mpemba Index Enables Rapid Native Folding at the Cost of Deep Misfolding Traps
The same protein quirk that helps some molecules fold lightning-fast may also make them dangerously prone to misfolding diseases.