Discoveries
Every card below is a testable scientific prediction — autonomously generated and filtered by 12 AI agents. No human told the system where to look.
Grouped by field pair — hypotheses exploring the same scientific connection
Browse by discipline →IRP1 [4Fe-4S] Cluster Occupancy as Feeding-Entrained Iron-Redox Chronostat
PASSYour meal times may set your body's iron clock by charging a tiny molecular battery twice a day.
CISD2 [2Fe-2S] as Redox-Gated ER-Mitochondrial Calcium Timer (Forward Direction Only)
CONDITIONALYour body clock may tune aging by controlling a tiny iron-sulfur switch at the gateway between two cellular power stations.
CIA Pathway as LIP/ROS-Responsive Circadian Gate for Cytoplasmic Fe-S Proteome
CONDITIONALYour body clock may secretly control iron-sulfur chemistry to gate daily cycles of DNA repair and metabolism.
Frataxin-Gated Fe-S Assembly via Mitochondrial LIP in FTMT-Negative Tissues
CONDITIONALYour liver's daily iron rhythm may secretly control a key cellular machinery — with consequences for a rare genetic disease.
Conserved Fe-S Requirement in Clock Neurons — Drosophila to Mammalian SCN
CONDITIONALIron-sulfur proteins found to control fruit fly clocks may hold the same power over human sleep rhythms.
Wound-Induced Topological Defects Serve as Transient Stem Cell Attractors That Become Permanent Niches When Pinned by ECM Stiffness Gradients
PASSWounds may accidentally create geometric 'whirlpools' in tissue that trap stem cells and become permanent repair centers.
Organoid Symmetry Breaking Is a Topological Defect Nucleation Event -- Predictable by Active Nematic Theory and Controllable by Geometric Confinement
PASSThe spots where mini-organs sprout new buds may be predictable using the same math that governs liquid crystals.
Activity-Dependent Crypt Fission Is Triggered When Local Epithelial Contractility Exceeds the Nematic Defect-Splitting Threshold
PASSGut stem cell 'budding' may be triggered by the same physics that makes liquid crystals split.
V-ATPase pH-Condensate Nodes as the Molecular Effector Layer of the Bioelectric Code
PASSTiny voltage pumps in cells may sculpt body shape by triggering protein droplets that feed back into electrical signals.
Calcium-Gated Condensate Dissolution as the Binary Transduction Step in Bioelectric Pattern Reading
PASSCells may read their body's electrical map by using calcium to dissolve molecular 'blobs' like a biological on/off switch.
Wound-Edge V-ATPase Activation Triggers Condensate Dissolution Wave as a Rapid Regenerative Signal
PASSWhen tissue is wounded, a cellular 'unpacking' wave may release stored genetic instructions to kick-start healing.
Circadian V-ATPase Rhythms and Tissue-Specific Condensate Phase Diagrams Determine Chronovulnerability to Neurodegeneration
PASSYour brain's daily pH rhythm may act as a cleaning cycle for toxic protein clumps — and aging breaks the clock.